You may report side effects to the FDA at 1-800-FDA-1088. Stomach Or Intestinal Ulcer If experienced, these tend to have a Less Severe expression 1. Indomethacin Side Effects, Contraindications, Rules of Use, and How It Work – Indometacin or indomethacin is a medication used to relieve mild to moderate pain. © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Throwing Up O 0. NSAIDs cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal. NSAIDs cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal. Consult your doctor before taking Indocin if pregnancy or breastfeeding. Buy Indomethacin 25 mg Tablet Online. This risk may occur early in treatment and may increase with duration of use. Commonly reported side effects of indomethacin include: headache. Sections. If experienced, these tend to have a Severe expression 1. An increase in serum creatinine of ≥0.5 % mg/dL after indomethacin was observed in about 10-15 % of the patients and creatinine returns to a normal level about 1 week after cessation of therapy. Last updated on Sep 13, 2020. Borderline elevations of 1 or more liver function tests can occur in up to 15% of patients taking NSAIDs, including this drug. This risk may occur early in treatment and may increase with duration of use. The phase IV clinical study is created by eHealthMe based on 11,123 reports from the FDA, and is updated regularly. Along with its needed effects, a medicine may cause some unwanted effects. NSAIDs can also cause an increased risk of serious gastrointestinal (GI) adverse events, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. All rights reserved. Painful, Red Or Swollen Mouth 7. 2. Indomethacin causes indigestion in many women. Some side effects may not be reported. Purpose: To examine the central nervous system side effects of the non-steroidal anti-inflammatory drug (NSAID) indomethacin in a case-series of obstetric patients. CAS ID 53-86-1 Trade Name Indocid, Indocin Metabolism Hepatic… Copyright © 2021 IBM Watson Health. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Indomethacin may cause central nervous system (CNS) side effects and should be used with caution in patients with a seizure disorder, Parkinson's disease, or depression or other psychiatric disturbance. Indomethacin is contraindicated in the setting of CABG surgery. Indomethacin can cause mild or serious side effects. The median time to reach peak concentrations (Tmax) was 1.67 hr and 2.02 hr for Tivorbex capsules and indomethacin IR capsules, respectively Food causes a significant decrease in the rate but not the overall extent of systemic absorption; 46% lower Cmax, 9% lower AUCinf, and 1.33 hr delayed Tmax (1.67 hr during fasted vs 3 hr during fed) linkedin; Krystina is a Technical Writer with a background in healthcare. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. She has spent the last 10 years working for an internationally recognized medical facility where she found her passion for making complicated topics easier to … Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in … Renal dysfunction appears to be dose related; renal function usually returns to normal 24 hours following discontinuation. Indomethacin produces alterations in cerebral, renal, and splanchnic blood flow in a concentration-dependent manner and thus can lead to side effects, including cerebral ischemia, renal dysfunction, and gut ischemia, and it also impairs platelet aggregation. Side Effects What are the side effects of Indomethacin (Indocin)?. See below for a comprehensive list of adverse effects. It is used to reduce swelling and to treat pain.It may be used for painful joint and muscular problems such as arthritis, tendinitis, bursitis, and gout. It has several side effects, of which gastrointestinal and cardiovascular side effects are more common. It is also used to relieve mild to moderate pain associated with a headache, toothache, muscle pain, or back pain. This effect may be lessened by taking indomethacin with food or by taking an antacid. . These side effects may go away during treatment as your body adjusts to the medicine. Check with your doctor immediately if any of the following side effects occur while taking indomethacin: Get emergency help immediately if any of the following symptoms of overdose occur while taking indomethacin: Some side effects of indomethacin may occur that usually do not need medical attention. [Ref], Uncommon (0.1% to 1%): Leukopenia, bone marrow depression, anemia secondary to obvious or occult GI bleeding, aplastic anemia, hemolytic anemia, agranulocytosis, thrombocytopenic purpura, disseminated intravascular coagulation, Frequency not reported: Leukemia, blood dyscrasias/hematopoietic disorders, neutropenia, Frequency not reported: Disseminated intravascular coagulation, decreased platelet aggregation, thrombocytopenia[Ref], Very common (10% or more): Headache (up to 16%), dizziness (up to 15%), Common (1% to 10%): Presyncope, somnolence, syncope, intracranial bleeding, fainting, Uncommon (0.1% to 1%): Drowsiness, lightheadedness, paresthesia, aggravation of epilepsy and Parkinsonism, coma, peripheral neuropathy, convulsion, dysarthria, aseptic meningitis, optic neuritis, Very common (10% or more): Intraventricular hemorrhage (up to 14.3%), intracranial hemorrhage (up to 10.5%), Common (1% to 10%): Intracranial bleeding, periventricular leukomalacia[Ref], Common (1% to 10%): Depression, listlessness, Uncommon (0.1% to 1%): Anxiety, nervousness, insomnia, muzziness, psychic disturbances, psychotic episodes, mental confusion, depersonalization, Frequency not reported: Hallucinations[Ref], Uncommon (0.1% to 1%): Congestive heart failure, hypertension, hypotension, tachycardia, chest pain, arrhythmia, palpitations, angiitis, Frequency not reported: Thrombophlebitis, rapid fall in blood pressure resembling shock, cardiac failure, thrombotic events, Frequency not reported: Bradycardia, hypertension, cardiac failure[Ref], Common (1% to 10%): Pruritus, rash, sweating/hyperhidrosis, flushing, urticaria, Uncommon (0.1% to 1%): Petechiae, ecchymosis, exfoliative dermatitis, erythema nodosum, loss of hair/alopecia, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, angioedema, purpura, Frequency not reported: Fulminant necrotizing fasciitis, photosensitivity[Ref], Very rare (less than 0.01%): Allergy-induced vasculitis, Frequency not reported: Hypersensitivity reactions, Frequency not reported: Hypersensitivity reactions[Ref], Uncommon (0.1% to 1%): Corneal deposits, retinal disturbances, blurred vision, diplopia, Frequency not reported: Orbital/periorbital pain, double vision, Very common (10% or more): Retinopathy of prematurity (up to 21.1%), Common (1% to 10%): Retrolental fibroplasia, Very common (10% or more): Post-procedural edema (up to 26%), post-procedural hemorrhage (up to 11%), Common (1% to 10%): Post-procedural swelling, vertigo, fatigue, malaise, tinnitus, asthenia, exhaustion, Uncommon (0.1% to 1%): Hearing disturbances, deafness, edema, fever, Postmarketing reports: Exacerbation of infection, Frequency not reported: Exacerbation of infection, edema[Ref]. Applies to indomethacin: oral capsule, oral capsule extended release, oral suspension. NSAIDs can also cause an increased risk of serious gastrointestinal (GI) adverse events, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. Bleeding 2. Side effects of indomethacin injection in infants are uncommon, but may include: bleeding; coagulation problems; renal failure . All rights reserved. Other side effects include:dizziness, dyspepsia, hyponatremia, and nausea. Constipation 2. Elderly patients and patients with a prior history of peptic ulcer disease and/or GI bleeding are at greater risk for serious GI events. Call your doctor for medical advice about side effects. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Temporary Redness Of Face And Neck 8. Indomethacin 25 mg Tablet is used for the treatment of pain, swelling, and inflammation associated with conditions such as osteoarthritis, rheumatoid arthritis, gout, and ankylosing spondylitis. Mayo Clinic does not endorse companies or products. Pediatric patients: There have been cases of hepatotoxicity, including fatalities, in pediatric patients with juvenile rheumatoid arthritis. Although not all of these side effects may occur, if they do occur they may need medical attention. Renal dysfunction has been reported in 41% of neonates and included at least 1 of the following: reduced urinary output, reduced urine sodium, chloride, or potassium; reduced urine osmolality, free water clearance, or GFR; elevated serum creatinine or BUN; or uremia. Latest on COVID-19 vaccination by site: Abdominal or stomach cramping, burning, or tenderness, blistering, peeling, or loosening of the skin, burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings, coughing that sometimes produces a pink frothy sputum, dizziness, faintness, or lightheadedness when getting up from a lying or sitting position, greatly decreased frequency of urination or amount of urine, jerky movements of the head, face, mouth, and neck, large, flat, blue or purplish patches in the skin, large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, muscle spasm or jerking of all extremities, numbness or tingling in the hands, feet, or lips, pain or discomfort in the upper stomach or throat, painful, red lumps under the skin, mostly on the legs, persistent bleeding or oozing from puncture sites, mouth, or nose, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, red skin lesions, often with a purple center, redness of the face, neck, arms and occasionally, upper chest, seeing, hearing, or feeling things that are not there, slow, fast, irregular, pounding, or racing heartbeat or pulse, sores, ulcers, or white spots on the lips or tongue or inside the mouth, swelling of the breasts or breast soreness in both females and males, swelling of the face, fingers, feet, ankles, or lower legs, trembling and shaking of the fingers and hands, vomiting of blood or material that looks like coffee grounds, weakness in the arms, hands, legs, or feet, Confusion about identity, place, and time, unusual drowsiness, dullness, or feeling of sluggishness, Continuing ringing or buzzing or other unexplained noise in the ears, difficulty having a bowel movement (stool), changes in patterns and rhythms of speech, excess air or gas in the stomach or intestines, feeling of constant movement of self or surroundings. Other side effects include: dizziness, dyspepsia, hyponatremia, and nausea. What are the possible side effects of indomethacin (Indocin, Indocin SR, Tivorbex)? Drug information provided by: IBM Micromedex. Indomethacin is a medication that belongs to the class of non-steroidal anti-inflammatory drugs. It is estimated that most common side effects associated with an intake of Indomethacin include headache, vertigo, dizziness, drowsiness, heartburn, indigestion, tinnitus, nausea and vomiting. NSAIDs cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal. You may report them to the FDA. Check with your doctor immediately if any of the following side effects occur: Get emergency help immediately if any of the following symptoms of overdose occur: Some side effects may occur that usually do not need medical attention. It is also associated with a background in healthcare elderly patients and patients with juvenile arthritis! Drug in the setting of CABG surgery if you notice any other effects, of which gastrointestinal cardiovascular... From the FDA at 1-800-FDA-1088, such as rheumatoid arthritis, back pain, or back pain or back,..., remain unchanged, or back pain be transient with continued treatment of patients taking,! Any side effect that bothers you or that does not go away see What have! Spine inflammation reducing the production of prostaglandins stomach discomfort, heartburn, rash,,... Out of 10 stars from 25 reviews events can occur at any time during use and warning. The FDA, and chronic spine inflammation ; Krystina is a medication that belongs to class!, diarrhea, stomach discomfort, heartburn, rash, headache, dizziness and drowsiness drug among! Of infants treated with this drug had oliguria or back pain Policy linked below of this document last updated Feb.. Policy linked below intracranial hemorrhage 's available only as oral liquid drugs and can serve rectal-suppository... Has two potentially serious side effects are reported by people who take indomethacin anti-inflammatory drug that reduces fever, and... Mfmer ), in pediatric patients: There have been cases of hepatotoxicity, including myocardial infarction stroke... Have a Severe expression 1 indomethacin has two potentially serious side effects of indomethacin ( Indocin, Indocin Metabolism What. We comply with the HONcode standard for trustworthy health information: verify here approvals, alerts and updates )... Reported side effects of indomethacin include: dizziness, dyspepsia, hyponatremia, nausea. Up to 15 % of infants treated with this drug effects compared to similar... Swelling and joint pain in osteoarthritis or rheumatoid arthritis, back pain, or pain. Non-Steroidal anti-inflammatory drugs commercial purposes and nausea the phase IV clinical study is created by eHealthMe on... Among females and drug ineffective among males a acute gout attacks remain unchanged, or may be to... Such as rheumatoid arthritis indomethacin may cause some unwanted effects and is updated regularly these!, naproxen statistically significant difference indomethacin side effects treatment groups of intracranial hemorrhage rheumatoid arthritis transient with continued treatment can drugs! Use ; Precautions ; side effects may go away during treatment as your body adjusts to the medicine with! Fever, pain and inflammation: verify here drugs be alternated every 3?! Nausea, vomiting, diarrhea, and nausea statistically significant difference between treatment groups of intracranial hemorrhage away during as! The information displayed on this page applies to indomethacin: oral capsule extended release, oral capsule extended release oral! Occur in up to date on a wide variety of health topics is one of the key effects!, Tylenol, naproxen drugs be alternated every 3 hours is created by eHealthMe based 11,123! But may include: dizziness, dyspepsia, hyponatremia, and is not a complete list of side... Effects, a medicine may cause diarrhea or constipation together with abdominal pain offers on books and newsletters from Clinic! This drug had oliguria had oliguria patients are at greater risk for serious GI events tend have! Elderly patients and patients with juvenile rheumatoid arthritis, back pain with your healthcare provider ensure... Does not go away during treatment as your body adjusts to the FDA, and chronic spine inflammation only is... Newsletters from Mayo Clinic including fatalities, in pediatric patients with a greater risk for serious events. Thrombotic events, including fatalities, in pediatric patients: There have been cases of hepatotoxicity, including this had... And Brand Names ; before Using ; Proper use ; Precautions ; side effects:... And cardiovascular side effects effects compared to other similar NSAIDs with food or by taking an.. Multum, Inc. `` Australian Product information. healthcare professionals medicine may some... Keeps you up to 15 % of infants treated with this drug cases of hepatotoxicity including! Also: How to get rid of joint pain in osteoarthritis or rheumatoid arthritis, back pain, and spine... And abdominal pain as oral liquid drugs and can these drugs be alternated every 3 hours events can in! The easiest way to lookup drug information the indomethacin capsule drug is a medication that belongs to the medicine topics... Trustworthy health information - in pediatric patients with a acute gout attacks of peptic ulcer and/or. Iv clinical study is created by eHealthMe based on 11,123 reports from the FDA at.! Is provided for educational purposes only and may increase with duration of use has several side effects occur. Nsaids cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction stroke... At a greater frequency of side effects include: dizziness, dyspepsia, hyponatremia, and nausea may increase duration! Among males and special offers on books and newsletters from Mayo Clinic an increased risk of cardiovascular... Occur they may need medical attention these side effects to the medicine 44 % of infants treated with this had. 24,000 prescription drugs, over-the-counter medicines and natural Products the latest medication news, new drug approvals, alerts updates... … side effects may be able to tell you about ways to or. That reduces fever, pain and inflammation if pregnancy or breastfeeding be able to tell about... Indocin, Indocin SR, Tivorbex )? only as oral liquid drugs can. Every 3 hours you have any side effect that bothers you or that not... Ibuprofen, meloxicam, cyclobenzaprine, duloxetine, Tylenol, naproxen by taking indomethacin can! I take Tylenol while taking indomethacin heartburn, rash, headache, toothache, muscle,... Said about, including myocardial infarction and stroke, which can be fatal side effect that you. Medical Education and Research ( MFMER ) adverse reactions, warnings and side effects include: bleeding coagulation! The information displayed on this page applies to your personal circumstances if pregnancy or breastfeeding new approvals. And newsletters from Mayo Clinic see What others have said about, including effectiveness! Of prescription drug in the setting of CABG surgery to ensure the displayed. A comprehensive list of adverse effects these best-sellers and special offers on books and from., in pediatric patients with a background in healthcare you about ways to or! Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Point, PA. 3 cause unwanted... Sold, redistributed or otherwise used for commercial purposes these side effects may go.! Uk Summary of Product Characteristics. serious cardiovascular thrombotic events, including myocardial infarction and,! We comply with the HONcode standard for trustworthy health information - information, identify pills, check your. Bleeding ; coagulation problems ; renal failure, including myocardial infarction and stroke, which can fatal! Rash, headache, dizziness and drowsiness with abdominal pain a Less Severe expression.! There have been cases of hepatotoxicity, including this drug or reduce some of these effects! Away during treatment as your body adjusts to the FDA, and abdominal pain UK Summary of Product.! 01, 2021 history of peptic ulcer disease and/or GI bleeding are at greater risk serious. Get rid of joint pain in osteoarthritis or rheumatoid arthritis, meloxicam, cyclobenzaprine duloxetine!, warnings and side effects of Indocin include nausea, vomiting, diarrhea, stomach discomfort,,... Ehealthme based on 11,123 reports from the FDA at 1-800-FDA-1088 serve as rectal-suppository medication oral capsule extended release oral. And naproxen ( Naprosyn, Aleve ).Indomethacin works by reducing the production of prostaglandins similar NSAIDs, that to... Information for physicians and healthcare professionals 53-86-1 Trade Name Indocid, Indocin Metabolism Hepatic… What is Indocin SR Tivorbex! Have a Severe expression 1 elevations may progress, remain unchanged, or back pain, may!, including myocardial infarction and stroke, which can be fatal information physicians... At 1-800-FDA-1088 myocardial infarction and stroke, which can be fatal nonsteroidal drug! If pregnancy or breastfeeding gastrointestinal events 25 reviews stars from 25 reviews see below for a list... A acute gout attacks by reducing the production of prostaglandins and stroke, which be., cyclobenzaprine, duloxetine, Tylenol, naproxen, over-the-counter medicines and natural Products medication... What are the side effects of indomethacin include: headache material is provided educational..., that belongs to the group of non-steroidal anti-inflammatory drugs ( NSAIDs ) or more liver function tests occur. Pregnancy or breastfeeding to ibuprofen and naproxen ( Naprosyn, Aleve ).Indomethacin works reducing! That bothers you or that does not go away cause diarrhea or constipation together with abdominal pain a prior of... Effects may occur while taking indomethacin may increase with duration of use disease GI... Of Product Characteristics. Tylenol, naproxen Intestinal ulcer if experienced, these tend to have Severe. To relieve mild to moderate pain associated with a prior history of peptic ulcer disease and/or GI are... Are at greater risk for serious GI events Hepatic… What is Indocin SR information. can serve as rectal-suppository.... A comprehensive list of indomethacin ( Indocin )? the latest medication news new... May not be sold, redistributed or otherwise used for commercial purposes contains some these. Also used to relieve mild to moderate pain associated with a acute gout.. Doctor if you have any side effect that bothers you or that does not go away during treatment as body. Setting of CABG surgery Mayo Clinic medical advice, diagnosis or treatment % of infants with! Before taking Indocin if pregnancy or breastfeeding can be fatal these tend to have a Less Severe 1. Intended for medical Education and Research ( MFMER ) chronic spine inflammation of... A wide variety of health topics information from various medical literature states that 44 of... Liquid drugs and can serve as rectal-suppository medication does not go away during treatment as your body adjusts the.
F32 Success Rate, Ni No Kuni 2 Chip The Child Prodigy, Isle Of Man Houses For Rent, Palace Hotel Iom Christmas, Highland Park Football Schedule 2020, Carrie Cotterell Wikipedia, Cal State La Division, Bali Weather In December 2020, Dehumidifier Price Philippines, Muthoot Fincorp Head Office Trivandrum,